Expiration dating and stability testing for human drug products

25-Dec-2019 06:28

expiration dating and stability testing for human drug products-19

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Size Reduction: Definition, objectives of size reduction, mechanisms of size reduction, factors affecting size reduction, laws governing energy and power requirements of a mills including ball mill, hammer mill, fluid energy mill.Size separation: Different techniques of size separation, sieves, sieve shakers, sedimentation tank, cyclone separators, bag fillers etc.Heat transfer: Concept of heat flow, applications of Fourier’s law, forced and natural convection, surface coefficients, boiling liquids, condensing vapors, heat exchangers, heat interchangers, radiation, black body, Stefan Boltzmann equation, Kirchoff’s law.Evaporation: Basic concept of phase equilibria, factor affecting evaporation, evaporators, film evaporators, single effect and multiple effect evaporators, Mathematical problems on evaporation.Screening of soil for organisms producing antibiotics, fermenter, its design, control of different parameters.Isolation of mutants, factors influencing rate of mutation. Isolation of fermentation products with special reference to penicillins, streptomycins tetracyclines and vitamin B12.Medical/Surgical accessories, diagnostic aids, appliances available in the market.

Drug Store Management and Inventory Control: Organization of drug store, Types of materials stocked, storage conditions; Purchase and Inventory Control principles, purchase procedures, Purchase order, Procurement and stocking; Drug distribution Systems in Hospitals: Out-patient dispensing, methods adopted; Dispensing of drugs to in-patients. Charging policy, labeling; Dispensing of drugs to ambulatory patients; Dispensing of controlled drugs, Dispensing of ancillary supplies; Central Sterile Supply Unit and their Management: Types of materials for sterilization, Packing of materials prior to sterilization, sterilization equipments, Supply of sterile materials.Importance of unit operations in manufacturing; Stoichiometry: Unit processes material and energy balances, molecular units, mole fraction, tie substance, gas laws, mole volume, primary and secondary quantities, equilibrium state, rate process, steady and unsteady states, dimensionless equations, dimensionless formulae, dimensionless groups, different types of graphic representation, mathematical problems.